The route of Imām Riḍā’s hijrah to Iran, as an important political, cultural, and religious event, has various signs and meanings that can be effective in explaining this cultural route to Iranian-Islamic society. This cultural route covers numerous events, diaries, rituals, works, and blessings considered by the Shiites and the followers of the Imām (as) over the centuries. The semiotics of the cultural route of Imām Riḍā’s hijrah to Iran describes, analyzes, and promotes awareness about its rich cultural dimensions. Paying attention to culture, in this route, by recognizing the Razavi symbols, can pave the way for development planning based on Razavi culture. This study aims to review and explain the relationship between semiotics and Razavi culture. The signs related to Razavi culture include pilgrimage and its manifestations in different places, shrines, and qadamgāhs. By using signs and symbols such as the entrance and exit gates that Imām Riḍā (as) passed through, saqqakhanas (water fountains), timpani playing ceremonies, and cultural monuments, the Razavi cultural routes are deepened. Also, pilgrimage rituals, movement of the celebrating or mourning groups in line with these routes on special days and occasions, as well as paying attention to Islamic architecture and urban planning along this route-from the general scale of the settlements to architectural details-can be fruitful in this regard